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Academic Writing

$10-30 USD

Closed
Posted over 8 years ago

$10-30 USD

Paid on delivery
In this i want to write, that can help students in future and i would like to answer the queries asked
Project ID: 8038767

About the project

8 proposals
Remote project
Active 9 yrs ago

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8 freelancers are bidding on average $24 USD for this job
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$29 USD in 2 days
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I have good experience in academic and article writing having been a writer for over the past 6 years. I have abilities in various writing styles such as APA, MLA, Chicago, and Harvard. My work is always original and timely. I can also submit some of my previous work on request. Thank you
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I have a published academic and a newspaper article in my repertoire. I can write fluently, clearly and can do research based writing. Please refer to the following paragraph from the published abstract I wrote as an evident to my statement. Base pair dynamics of non-Watson & Crick U•U pair: Implications in Myotonic Dystrophy. Ananth Prakash, Costerwell Khyriem and N. Yathindra Abundant expansion of trinucleotide repeats is implicated in broad range of neurological diseases termed Trinucleotide Repeat Expansion Disorders (TREDs). The human Myotonic Dystrophy type 1 (DM1), a multi-systemic disorder, is associated with the occurrence of large copies of trinucleotide CUG repeats in the dystrophia myotonica-protein kinase (DMPK) transcript. These assemble into RNA duplexes comprising the canonical Watson & Crick (WC) base pairs interspersed with non-Watson & Crick (nWC) U·U base pairs. Repeats comprising U·U base pairs sequester MBNL-1 protein and modulates its intended function of mRNA splicing leading to DM1. Although much is known about the etiology of DM1, not much is understood about the underlying structural role. We examine the mechanistic effects of U·U base pairs on RNA duplex using molecular dynamics simulations. Results indicate a dynamic behaviour of U·U base pairs with different hydrogen bonding schemes, that not only dictate base pair stability but also influence global RNA structure with implications on protein recognition and binding.
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Member since Jul 10, 2015

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