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PHYLOGENETIC INFERENCE, GENE DISCOVERY AND FUNCTIONAL ANALYSIS WITHIN A REGION OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
1. You are requested to investigate the evolutionary history of CFB and C2 through phylogenetic analysis of available protein sequences. These genes are paralogues, and hence share a common ancestral gene. You will download CFB, C2 and CFB/C2-like sequences from a number of species, multiply align them and infer phylogenetic trees using several methods. You will choose the ‘best’ repre...